Changing epidemiology of HIV-associated cryptococcosis in sub-Saharan Africa

Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Meintjes, Graeme and Scriven, James (2016) 'Changing epidemiology of HIV-associated cryptococcosis in sub-Saharan Africa'. Lancet Infectious Diseases, Vol 16, Issue 8, pp. 891-892.

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Abstract

We read with interest the recent dose-finding study by Joshua Rhein and colleagues1 examining the use of sertraline alongside amphotericin B in the treatment of HIV-associated cryptococcal meningitis, and agree that further clinical trials are required to assess the possible benefit of this therapy. As noted in the linked Comment, cryptococcosis has not disappeared following the rollout of antiretroviral therapy (ART); 53% of the participants enrolled in the sertraline study were taking ART, suggesting a change in the epidemiology of HIV-associated cryptococcosis in sub-Saharan Africa during the past 5–10 years.

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology WC Communicable Diseases > Mycoses > WC 475 Cryptococcosis. Sporotrichosis WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503 Acquired immunodeficiency syndrome. HIV infections WC Communicable Diseases > Virus Diseases > Acquired Immunodeficiency Syndrome. HIV Infections > WC 503.5 Complications
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/S1473-3099(16)30145-1
Depositing User:	Stacy Murtagh
Date Deposited:	24 Aug 2016 11:31
Last Modified:	15 Dec 2021 12:48
URI:	https://archive.lstmed.ac.uk/id/eprint/6077

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