Modulating host immune responses to fight invasive fungal infections.

Scriven, James, Tenforde, Mark W, Levitz, Stuart M and Jarvis, Joseph N (2017) 'Modulating host immune responses to fight invasive fungal infections.'. Current Opinion in Microbiology, Vol 40, pp. 95-103.

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Abstract

Modulation of host immunity in invasive fungal infection is an appealing but as yet mostly elusive treatment strategy. Animal studies in invasive candidiasis and aspergillosis have demonstrated beneficial effects of colony stimulating factors, interferon-gamma and monoclonal antibodies. More recent studies transfusing leukocytes pre-loaded with lipophilic anti-fungal drugs, or modulated T-cells, along with novel vaccination strategies show great promise. The translation of immune therapies into clinical studies has been limited to date but this is changing and the results of new Candida vaccine trials are eagerly awaited. Immune modulation in HIV-associated mycoses remains complicated by the risk of immune reconstitution inflammatory syndrome and although exogenous interferon-gamma therapy may be beneficial in cryptococcal meningitis, early initiation of anti-retroviral therapy leads to increased mortality. Further study is required to better target protective immune responses. [Abstract copyright: Copyright © 2017. Published by Elsevier Ltd.]

Item Type:	Article
Subjects:	QW Microbiology and Immunology > Fungi. Pathogenic Fungi. > QW 180 Pathogenic Fungi QW Microbiology and Immunology > Immunity by Type > QW 568 Cellular immunity. Immunologic cytotoxicity. Immunocompetence. Immunologic factors (General) WC Communicable Diseases > Mycoses > WC 450 Mycoses (General or not elsewhere classified) WD Disorders of Systemic, Metabolic or Environmental Origin, etc > Metabolic Diseases > General Metabolic Diseases > WD 200 General works
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/j.mib.2017.10.018
SWORD Depositor:	JISC Pubrouter
Depositing User:	Stacy Murtagh
Date Deposited:	03 Jan 2018 13:24
Last Modified:	01 Dec 2018 02:02
URI:	https://archive.lstmed.ac.uk/id/eprint/7916

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