Could omics unlock the secret of surviving tuberculous meningitis?

Dunstan, Sarah and Caws, Maxine ORCID: https://orcid.org/0000-0002-9109-350X (2018) 'Could omics unlock the secret of surviving tuberculous meningitis?'. Lancet Infectious Diseases, Vol 18, Issue 5, pp. 479-480.

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Abstract

Despite devastating mortality among patients with tuberculosis meningitis, little progress has been made in understanding the pathophysiology of this disease since the landmark autopsy studies of Rich and McCordick in the 1930s.1 Even with treatment, two-thirds of patients die or are left with severe neurological deficits, including cognitive impairment, epilepsy, and paralysis.2 In The Lancet Infectious Diseases, Arjan van Laarhoven and colleagues3 present an elegant systems biology (or multi-omics) approach designed to elucidate the underlying mechanisms that cause these dire outcomes and ultimately aiming to identify new approaches to therapeutics.

Item Type:	Article
Subjects:	WF Respiratory System > Tuberculosis > WF 200 Tuberculosis (General) WL Nervous System > WL 200 Meninges. Blood-brain barrier
Faculty: Department:	Clinical Sciences & International Health > Clinical Sciences Department Clinical Sciences & International Health > International Public Health Department
Digital Object Identifer (DOI):	https://doi.org/10.1016/S1473-3099(18)30055-0
Depositing User:	JISC Pubrouter
Date Deposited:	09 Feb 2018 11:24
Last Modified:	23 Jul 2018 01:02
URI:	https://archive.lstmed.ac.uk/id/eprint/8213

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