Jochems, Simon ORCID: https://orcid.org/0000-0002-4835-1032, Marcon, Fernando, Carniel, Beatriz F., Holloway, Mark, Mitsi, Elena, Smith, Emma, Gritzfeld, Jenna, SolorzanoGonzalez, Carla, Reiné, Jesús, Pojar, Sherin ORCID: https://orcid.org/0000-0002-7746-3279, Nikolaou, Elissavet, German, Esther, Hyder-Wright, Angela, Hill, Helen, Hales, Caz, de Steenhuijsen Piters, Wouter A.A, Bogaert, Debby, Adler, Hugh ORCID: https://orcid.org/0000-0003-4437-2298, Zaidi, Seher, Connor, Victoria, Rylance, Jamie ORCID: https://orcid.org/0000-0002-2323-3611, Nakaya, Helder I and Ferreira, Daniela ORCID: https://orcid.org/0000-0002-0594-0902 (2018) 'Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage'. Nature Immunology, Vol 19, Issue 12, pp. 1299-1308.
Text
N_immunology_inflammation induced by influenza virus.docx - Accepted Version Download (6MB) |
Abstract
Secondary bacterial pneumonia following influenza infection is a significant cause of mortality worldwide. Upper respiratory tract pneumococcal carriage is important as both determinants of disease and population transmission. The immunological mechanisms that contain pneumococcal carriage are well-studied in mice but remain unclear in humans. Loss of this control of carriage following influenza infection is associated with secondary bacterial pneumonia during seasonal and pandemic outbreaks. We used a human type 6B pneumococcal challenge model to show that carriage acquisition induces early degranulation of resident neutrophils and recruitment of monocytes to the nose. Monocyte function associated with clearance of pneumococcal carriage. Prior nasal infection with live attenuated influenza virus induced inflammation, impaired innate function and altered genome-wide nasal gene responses to pneumococcal carriage. Levels of the cytokine IP-10 promoted by viral infection at the time of pneumococcal encounter was positively associated with bacterial density. These findings provide novel insights in nasal immunity to pneumococcus and viral-bacterial interactions during co-infection.
Item Type: | Article |
---|---|
Subjects: | QW Microbiology and Immunology > Viruses > QW 160 Viruses (General). Virology WC Communicable Diseases > Infection. Bacterial Infections > Bacterial Infections > WC 217 Pneumococcal infections WC Communicable Diseases > Virus Diseases > Viral Respiratory Tract Infections. Respirovirus Infections > WC 515 Human influenza WF Respiratory System > WF 100 General works |
Faculty: Department: | Clinical Sciences & International Health > Clinical Sciences Department |
Digital Object Identifer (DOI): | https://doi.org/10.1038/s41590-018-0231-y |
Depositing User: | Stacy Murtagh |
Date Deposited: | 31 Oct 2018 09:39 |
Last Modified: | 13 Mar 2020 16:19 |
URI: | https://archive.lstmed.ac.uk/id/eprint/9017 |
Statistics
Actions (login required)
Edit Item |