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Items where LSTM Author is "Biagini, Giancarlo"

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Hong, David, Leung, S, Amporndanai, Kangsa, Davies, Jill, Priestley, Richard, Nixon, Gemma L., Berry, Neil G., Samar Hasnain, S., Antonyuk, Svetlana, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and O’Neill, Paul M. (2018) 'Potent Antimalarial 2-Pyrazolyl Quinolone bc1 (Qi) Inhibitors with Improved Drug-like Properties'. ACS Medicinal Chemistry Letters, Vol 9, Issue 12, pp. 1205-1210.

O' Neill, Paul M, Stocks, Paul A, Sabbani, Sunil, Roberts, Natalie L, Amewu, Richard K, Shore, Emma R, Aljayyoussi, Ghaith, Angulo-Barturén, Iñigo, Belén, María, Díaz, Jiménez, Bazaga, Santiago Ferrer, Martínez, María Santos, Campo, Brice, Sharma, Raman, Charman, Susan A, Ryan, Eileen, Chen, Gong, Shackleford, David M, Davies, Jill, Nixon, Gemma L, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2018) 'Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.'. Bioorganic and Medicinal Chemistry, Vol 26, Issue 11, pp. 2996-3005.

O'Neill, Paul M, Amewu, Richard K, Charman, Susan A, Sabbani, Sunil, Gnädig, Nina F, Straimer, Judith, Fidock, David A, Shore, Emma R, Roberts, Natalie L, Wong, Michael H-L, Hong, W David, Pidathala, Chandrakala, Riley, Chris, Murphy, Ben, Aljayyoussi, Ghaith, Gamo, Francisco Javier, Sanz, Laura, Rodrigues, Janneth, Cortes, Carolina Gonzalez, Herreros, Esperanza, Angulo-Barturén, Iñigo, Jiménez-Díaz, María Belén, Bazaga, Santiago Ferrer, Martínez-Martínez, María Santos, Campo, Brice, Sharma, Raman, Ryan, Eileen, Shackleford, David M, Campbell, Simon, Smith, Dennis A, Wirjanata, Grennady, Noviyanti, Rintis, Price, Ric N, Marfurt, Jutta, Palmer, Michael J, Copple, Ian M, Mercer, Amy E, Ruecker, Andrea, Delves, Michael J, Sinden, Robert E, Siegl, Peter, Davies, Jill, Rochford, Rosemary, Kocken, Clemens H M, Zeeman, Anne-Marie, Nixon, Gemma L, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2017) 'A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.'. Nature Communications, Vol 8, e15159.

Hong, David, Gibbons, Peter, Leung, Suet C, Amewu, Richard, Stocks, Paul A, Stachulski, Andrew, Horta, Pedro, Cristiano, Maria L. S., Shone, Alison, Moss, Darren, Ardrey, Alison, Sharma, Raman, Warman, Ashley, Bedingfield, Paul, Fisher, Nicholas, Aljayyoussi, Ghaith, Mead, Sally, Caws, Maxine ORCID: https://orcid.org/0000-0002-9109-350X, Berry, Neil, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, O’Neill, Paul M and Nixon, Gemma L (2017) 'Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis'. Journal of Medicinal Chemistry, Vol 60, Issue 9, pp. 3703-3726.

Aljayyoussi, Ghaith, Jenkins, Victoria, Sharma, Raman, Donnellan, Samantha, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2017) 'Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration'. Scientific Reports, Vol 7, Issue 502.

Ullah, Imran, Sharma, Raman, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Horrocks, Paul (2017) 'A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials'. Journal of Antimicrobial Chemotherapy, Vol 72, Issue 3, pp. 717-726.

Aljayyoussi, Ghaith, Kay, Katherine, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2016) 'OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.'. Malaria Journal, Vol 15, Issue 344.

Ismail, Hanafy, Barton, Victoria E., Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, Paul M. (2016) 'A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile'. Angewandte Chemie International Edition, Vol 128, Issue 22, pp. 6401-6405.

Ismail, Hanafy, Barton, Victoria, Phanchana, Matthew, Charoensutthivarakul, Sitthivut, Wong, Michael H L, Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, O’Neill, Paul M and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2016) 'Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7'. Proceedings of the National Academy of Sciences, Vol 113, Issue 8, pp. 2080-2085.

McConville, Matthew, Fernández, Jorge, Angulo-Barturen, Íñigo, Bahamontes-Rosa, Noemi, Ballell-Pages, Lluis, Castañeda, Pablo, de Cózar, Cristina, Crespo, Benigno, Guijarro, Laura, Jiménez-Díaz, María Belén, Martínez-Martínez, Maria S, de Mercado, Jaime, Santos-Villarejo, Ángel, Sanz, Laura M, Frigerio, Micol, Washbourn, Gina, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Nixon, Gemma L, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Berry, Neil G, Blackman, Michael J, Calderón, Félix and O'Neill, Paul M (2015) 'Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.'. Journal of medicinal chemistry, Vol 58, Issue 16, pp. 6448-6455.

Charoensutthivarakul, Sitthivut, David Hong, W., Leung, Suet C., Gibbons, Peter D., Bedingfield, Paul, Nixon, Gemma L., Lawrenson, Alexandre S., Berry, Neil G., Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and O'Neill, Paul (2015) '2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties'. MedChemComm, Vol 6, Issue 7, pp. 1252-1259.

Capper, Michael J., O’Neill, Paul M., Fisher, Nicholas, Strange, Richard W., Moss, Darren M., Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Berry, Neil G., Lawrenson, Alexandre S., Hasnain, S. Samar, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Antonyuk, Svetlana V. (2015) 'Antimalarial 4(1H)-pyridones bind to the Qisite of cytochromebc1'. Proceedings of the National Academy of Sciences, Vol 112, Issue 3, pp. 755-760.

Antoine, Thomas, Fisher, Nicholas, Amewu, R., O'Neill, P. M., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2014) 'Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential'. Journal of Antimicrobial Chemotherapy, Vol 69, Issue 4, pp. 1005-1016.

Salcedo, Enrique, Caamno-Gutierrez, Eva, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2014) 'The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development'. Trends in Parasitology, Vol 30, Issue 4, pp. 170-175.

Stocks, P.A., Barton, V., Antoine, T., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, P. M. (2014) 'Novel inhibitors of the Plasmodium falciparum electron transport chain'. Parasitology, Vol 141, Issue 1, pp. 50-65.

Ressurreição, Ana S, Gonçalves, Daniel, Sitoe, Ana R, Albuquerque, Inês S, Gut, Jiri, Góis, Ana, Gonçalves, Lídia M, Bronze, Maria R, Hanscheid, Thomas, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Rosenthal, Philip J, Prudêncio, Miguel, O'Neill, Paul, Mota, Maria M, Lopes, Francisca and Moreira, Rui (2013) 'Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability.'. Journal of Medicinal Chemistry, Vol 56, Issue 19, pp. 7679-7690.

Nixon, Gemma, Pidathala, Chandrakala, Shone, Alison E, Antoine, Thomas, Fisher, Nicholas, O'Neill, Paul M, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2013) 'Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.'. Future medicinal chemistry, Vol 5, Issue 13, pp. 1573-1591.

Nixon, Gemma, Moss, Darren M., Shone, Alison, Lalloo, David ORCID: https://orcid.org/0000-0001-7680-2200, Fisher, Nicholas, O'Neill, Paul M, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2013) 'Antimalarial pharmacology and therapeutics of atovaquone.'. The Journal of Antimicrobial Chemotherapy, Vol 68, Issue 5, pp. 977-985.

Warman, Ashley, Rito, Teresa S, Fisher, Nicholas, Moss, Darren M., Berry, Neil G, O'Neill, Paul M, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2013) 'Antitubercular pharmacodynamics of phenothiazines'. Journal of Antimicrobial Chemotherapy, Vol 68, Issue 4, pp. 869-880.

van Schalkwyk, Donelly A., Saliba, Kevin J., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Bray, Patrick and Kirk, Kiaran (2013) 'Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress'. PLoS ONE, Vol 8, Issue 3, e58933.

Salcedo, Enrique, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2012) 'A yeast expression system for functional and pharmacological studies of the malaria parasite Ca2+/H+ antiporter.'. Malaria Journal, Vol 11, p. 254.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Fisher, Nicholas, Shone, Alison, Mubaraki, Murad A., Srivastava, Abhishek, Hill, Alasdair, Antoine, Thomas, Warman, Ashley, Davies, Jill, Pidathala, Chandrakala, Amewu, Richard K, Leung, Suet C, Sharma, Raman, Gibbons, Peter, Hong, David W, Pacorel, Bénédicte, Lawrenson, Alexandre S, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Stocks, Paul A., Nixon, Gemma, Chadwick, James, Hemingway, Janet ORCID: https://orcid.org/0000-0002-3200-7173, Delves, Michael J, Sinden, Robert E, Zeeman, Anne-Marie, Kocken, Clemens H M, Berry, Neil G, O'Neill, Paul M and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2012) 'Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.'. Proceedings of the National Academy of Sciences of the United States of America, Vol 109, Issue 21, pp. 8298-303.

Vallières, Cindy, Fisher, Nicholas, Antoine, Thomas, Al-Helal, Mohammed, Stocks, Paul A., Berry, Neil G, Lawrenson, Alexandre S, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, O'Neill, Paul M, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Meunier, Brigitte (2012) 'HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.'. Antimicrobial Agents and Chemotherapy, Vol 56, Issue 7, pp. 3739-47.

Sharma, Raman, Lawrenson, Alexandre S, Fisher, Nicholas, Warman, Ashley, Shone, Alison, Hill, Alasdair, Mbekeani, Alison, Pidathala, Chandrakala, Amewu, Richard K, Leung, Suet, Gibbons, Peter, Hong, David W, Stocks, Paul A., Nixon, Gemma L, Chadwick, James, Shearer, Joanne, Gowers, Ian, Cronk, David, Parel, Serge P, O'Neill, Paul M, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Berry, Neil G (2012) 'Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.'. Journal of medicinal chemistry, Vol 55, Issue 7, pp. 3144-54.

Fisher, Nicholas, Abd Majid, Roslaini, Antoine, Thomas, Al-Helal, Mohammed, Warman, Ashley, Johnson, David, Lawrenson, Alexandre S., Ranson, Hilary ORCID: https://orcid.org/0000-0003-2332-8247, O'Neill, Paul M, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2012) 'Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.'. The Journal of Biological Chemistry, Vol 287, Issue 13, pp. 9731-9741.

Pidathala, Chandrakala, Amewu, Richard, Pacorel, Bénédicte, Nixon, Gemma L, Gibbons, Peter, Hong, W David, Leung, Suet C, Berry, Neil G, Sharma, Raman, Stocks, Paul A., Srivastava, Abhishek, Shone, Alison, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas, Warman, Ashley, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, Paul M (2012) 'Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).'. Journal of medicinal chemistry, Vol 55, Issue 5, pp. 1831-1843.

Leung, Suet C, Gibbons, Peter, Amewu, Richard, Nixon, Gemma L, Pidathala, Chandrakala, Hong, W David, Pacorel, Bénédicte, Berry, Neil G, Sharma, Raman, Stocks, Paul A., Srivastava, Abhishek, Shone, Alison, Charoensutthivarakul, Sitthivut, Taylor, Lee, Berger, Olivier, Mbekeani, Alison, Hill, Alasdair, Fisher, Nicholas, Warman, Ashley, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, Paul M (2012) 'Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).'. Journal of medicinal chemistry, Vol 55, Issue 5, pp. 1844-1857.

Cowley, Robin, Leung, Suet, Fisher, Nicholas, Al-Helal, Mohammed, Berry, Neil G., Lawrenson, Alexandre S., Sharma, Raman, Shone, Alison, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and O′Neill, Paul M. (2012) 'The development of quinolone esters as novel antimalarial agents targeting the Plasmodium falciparum bc1 protein complex'. MedChemComm, Vol 3, Issue 1, pp. 39-44.

Salcedo, Enrique, Ochong, Edwin, Beveridge, Susan, Johnson, David, Nzila, Alexis, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Stocks, Paul A., O'Neill, Paul M, Krishna, Sanjeev, Bray, Patrick and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2011) 'The molecular basis of folate salvage in Plasmodium falciparum: Characterization of two folate transporters.'. The Journal of Biological Chemistry, Vol 286, Issue 52, pp. 44659-44668.

Berger, Olivier, Kaniti, Archana, Ba, Christophe Tran van, Vial, Henri, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Bray, Patrick and O'Neill, Paul M (2011) 'Synthesis and Antimalarial Activities of a Diverse Set of Ariazole-Containing Furamidine Analogues.'. ChemMedChem, Vol 6, Issue 11, pp. 2094-2108.

Rodrigues, Tiago, Moreira, Rui, Gut, Jiri, Rosenthal, Philip J, O Neill, Paul M, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Lopes, Francisca, Dos Santos, Daniel J V A and Guedes, Rita C (2011) 'Identification of new antimalarial leads by use of virtual screening against cytochrome bc(1).'. Bioorganic and Medicinal Chemistry, Vol 19, Issue 21, pp. 6302-8.

Gibbons, Peter, Verissimo, Edite, Araujo, Nuna C, Barton, Victoria, Nixon, Gemma L, Amewu, Richard K, Chadwick, James, Stocks, Paul A., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Srivastava, Abhishek, Rosenthal, Philip J, Gut, Jiri, Guedes, Rita C, Moreira, Rui, Sharma, Raman, Berry, Neil, Cristiano, M Lurdes S, Shone, Alison, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, Paul M (2010) 'Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity.'. Journal of medicinal chemistry, Vol 53, Issue 22, pp. 8202-6.

Lucumi, Edinson, Darling, Claire, Jo, Hyunil, Napper, Andrew D., Chandramohanadas, Rajesh, Fisher, Nicholas, Shone, Alison, Jing, Huiyan, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, DeGrado, William F, Diamond, Scott L and Greenbaum, Doron C (2010) 'Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.'. Antimicrobial Agents and Chemotherapy, Vol 54, Issue 9, pp. 3597-3604.

Barton, Victoria, Fisher, Nicholas, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and O'Neill, Paul M. (2010) 'Inhibiting Plasmodium cytochrome bc1: a complex issue.'. Current Opinion in Chemical Biology, Vol 14, Issue 4, pp. 440-446.

Henry, Roselani I, Cobbold, Simon A., Allen, Richard J. W., Khan, Asif, Hayward, Rhys, Lehane, Adele M., Bray, Patrick, Howitt, Susan M., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Saliba, Kevin J. and Kirk, Kiaran (2010) 'An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum.'. The Journal of Biological Chemistry, Vol 285, Issue 24, pp. 18615-18626.

Hughes, Katie R, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Craig, Alister ORCID: https://orcid.org/0000-0003-0914-6164 (2010) 'Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment.'. Molecular and biochemical parasitology, Vol 169, Issue 2, pp. 71-78.

Kongkathip, Ngampong, Pradidphol, Narathip, Hasitapan, Komkrit, Grigg, Ronald, Kao, Wei-Chun, Hunte, Carola, Fisher, Nicholas, Warman, Ashley, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Kongsaeree, Palangpon, Chuawong, Pitak and Kongkathip, Boonsong (2010) 'Transforming rhinacanthin analogues from potent anticancer agents into potent antimalarial agents.'. Journal of medicinal chemistry, Vol 53, Issue 3, pp. 1211-1221.

O'Neill, Paul M., Shone, Alison, Stanford, Deborah, Nixon, Gemma, Asadollahy, Eghbaleh, Park, B. Kevin, Maggs, James L., Roberts, Phil, Stocks, Paul A., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Bray, Patrick, Davies, Jill, Berry, Neil, Hall, Charlotte, Rimmer, Karen, Winstanley, Peter A., Hindley, Stephen, Bambal, Ramesh B., Davis, Charles B., Bates, Martin, Gresham, Stephanie L., Brigandi, Richard A., Gomez-de-las-Heras, Federico M., Gargallo, Domingo V., Parapini, Silvia, Vivas, Livia, Lander, Hollie, Taramelli, Donatella and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2009) 'Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4′-Fluoro and 4′-Chloro Analogues of Amodiaquine. Identification of a Suitable “Back-Up” Compound for N-tert-Butyl Isoquine'. Journal of Medicinal Chemistry, Vol 52, Issue 7, pp. 1828-1844.

Lian, L. Y., Al-Helal, Mohammed, Roslaini, A. M., Fisher, Nicholas, Bray, Patrick, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2009) 'Glycerol: An unexpected major metabolite of energy metabolism by the human malaria parasite'. Malaria Journal, Vol 8, p. 38.

O'Neill, Paul M., Park, B. Kevin, Shone, Alison, Maggs, James L., Roberts, Phillip, Stocks, Paul A., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Bray, Patrick, Gibbons, Peter, Berry, Neil, Winstanley, Peter A., Mukhtar, Amira, Bonar-Law, Richard, Hindley, Stephen, Bambal, Ramesh B., Davis, Charles B., Bates, Martin, Hart, Timothy K., Gresham, Stephanie L., Lawrence, Ron M., Brigandi, Richard A., Gomez-delas-Heras, Federico M., Gargallo, Domingo V. and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2009) 'Candidate Selection and Preclinical Evaluation of N-tert-Butyl Isoquine (GSK369796), An Affordable and Effective 4-Aminoquinoline Antimalarial for the 21st Century'. Journal of Medicinal Chemistry, Vol 52, Issue 5, pp. 1408-1415.

Fisher, Nicholas, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2008) 'Modelling, cloning and expression of the P.falciparum NADH dehydrogenase'. Biochimica Et Biophysica Acta-Bioenergetics, Vol 1777, S38-S38.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Fisher, Nicholas, Berry, N., Stocks, Paul A., Meunier, B., Williams, D. P., Bonar-Law, R., Bray, Patrick, Owen, A., O'Neill, P. M. and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2008) 'Acridinediones: Selective and potent inhibitors of the malaria parasite mitochondrial bc(1) complex'. Molecular Pharmacology, Vol 73, Issue 5, pp. 1347-1355.

Quashie, N. B., Dorin-Semblat, D., Bray, Patrick, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Doerig, C., Ranford-Cartwright, L. C. and de Koning, H. P. (2008) 'A comprehensive model of purine uptake by the malaria parasite Plasmodium falciparum: identification of four purine transport activities in intraerythrocytic parasites'. Biochemical Journal, Vol 411, Issue 2, pp. 287-295.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Fisher, Nicholas, Berry, N., Stocks, Paul A., Meunier, B., Bray, Patrick, Owen, A., O'Neill, P. and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2008) 'Acridinediones: a new class of potent inhibitors selective against the mitochondrial bc1 complex of the malaria parasite Plasmodium falciparum.'. International Journal for Parasitology, Vol 38, Issue Supplement 1, S41-S41.

Fisher, Nicholas, Bray, Patrick, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2007) 'Malaria-parasite mitochondrial dehydrogenases as drug targets: too early to write the obituary'. Trends in Parasitology, Vol 24, Issue 1, pp. 9-10.

Stocks, Paul A., Bray, Patrick, Barton, V. E., Al-Helal, Mohammed, Jones, M., Araujo, N. C., Gibbons, P., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Hughes, Ruth, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Davies, Jill, Amewu, R., Mercer, A. E., Ellis, G. and O'Neill, P. M. (2007) 'Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs'. Angewandte Chemie-International Edition, Vol 46, Issue 33, pp. 6278-6283.

Fisher, Nicholas, Bray, Patrick, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2007) 'The malaria parasite type IINADH : quinone oxidoreductase: an alternative enzyme for an alternative lifestyle'. Trends in Parasitology, Vol 23, Issue 7, pp. 305-310.

Harris, K. M., Goldberg, B., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Lloyd, D. (2007) 'Trichomonas vaginalis and Giardia intestinalis produce nitric oxide.'. Journal of Eukaryotic Microbiology, Vol 54, Issue 2, 41s-42s.

Harris, K. M., Goldberg, B., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 and Lloyd, D. (2006) 'Trichomonas vaginalis and Giardia intestinalis produce nitric oxide and display NO-synthase activity'. Journal of Eukaryotic Microbiology, Vol 53, Issue S1, S182-S183.

Richier, E., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Wein, S., Boudou, F., Bray, Patrick, Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192, Precigout, E., Calas, M., Dubremetz, J. F. and Vial, H. J. (2006) 'Potent antihematozoan activity of novel bisthiazolium drug T16: Evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp.'. Antimicrobial Agents and Chemotherapy, Vol 50, Issue 10, pp. 3381-3388.

Bray, Patrick, Mungthin, M., Hastings, Ian ORCID: https://orcid.org/0000-0002-1332-742X, Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Saidu, D. K., Lakshmanan, V., Johnson, David, Hughes, Ruth, Stocks, Paul A., O'Neill, P. M., Fidock, D. A., Warhurst, D. C. and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2006) 'PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX'. Molecular Microbiology, Vol 62, Issue 1, pp. 238-251.

Edwards, Geoffrey and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2006) 'Resisting resistance: dealing with the irrepressible problem of malaria'. British Journal of Clinical Pharmacology, Vol 61, Issue 6, pp. 690-693.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Viriyavejakul, P., O'Neill, P. M., Bray, Patrick and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2006) 'Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria'. Antimicrobial Agents and Chemotherapy, Vol 50, Issue 5, pp. 1841-1851.

O'Neill, P. M., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192, Berry, N. G., Jeyadevan, J. P., Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Asadollaly, E., Park, B. K. and Bray, Patrick (2006) 'A medicinal chemistry perspective on 4-aminoquinoline antimalarial drugs'. Current Topics in Medicinal Chemistry, Vol 6, Issue 5, pp. 479-507.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Fidock, D. A., Bray, Patrick and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2005) 'Mutations conferring drug resistance in malaria parasite drug transporters Pgh1 and PfCRT do not affect steady-state vacuolar Ca2+ [Letter to the Editor]'. Antimicrobial Agents and Chemotherapy, Vol 49, Issue 11, pp. 4807-4808.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, O'Neill, P. M., Bray, Patrick and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2005) 'Current drug development portfolio for antimalarial therapies'. Current Opinion in Pharmacology, Vol 5, Issue 5, pp. 473-478.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Bray, Patrick (2005) 'Malaria parasite transporters as a drug-delivery strategy'. Trends in Parasitology, Vol 21, Issue 7, pp. 299-301.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Pasini, E. M., Hughes, Ruth, De Koning, H. P., Vial, H. J., O'Neill, P. M., Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Bray, Patrick (2004) 'Characterization of the choline carrier of Plasmodium falciparum: a route for the selective delivery of novel antimalarial chugs'. Blood, Vol 104, Issue 10, pp. 3372-3377.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, O'Neill, Paul M., Nzila, Alexis, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Bray, Patrick (2003) 'Antimalarial chemotherapy: young guns or back to the future?'. Trends in Parasitology, Vol 19, Issue 11, pp. 479-487.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Richier, E., Bray, Patrick, Calas, M., Vial, H. and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2003) 'Heme binding contributes to antimalarial activity of bis-quaternary ammoniums'. Antimicrobial Agents and Chemotherapy, Vol 47, Issue 8, pp. 2584-2589.

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Bray, Patrick, Spiller, D. G., White, M. R. H. and Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 (2003) 'The digestive food vacuole of the malaria parasite is a dynamic intracellular Ca2+ store'. Journal of Biological Chemistry, Vol 278, Issue 30, pp. 27910-27915.

Book Section

Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595, Bray, Patrick and Ward, Steve ORCID: https://orcid.org/0000-0003-2331-3192 (2017) 'Mechanisms of Antimalarial Drug Resistance' in: Meyers, Douglas L., (ed) Antimicrobial Drug Resistance, Mechanisms of Drug Resistance, Volume 1, Cham, Switzerland, Springer, pp. 629-647.

Fisher, Nicholas, Warman, Ashley, Ward, Stephen ORCID: https://orcid.org/0000-0003-2331-3192 and Biagini, Giancarlo ORCID: https://orcid.org/0000-0001-6356-6595 (2010) 'Chapter 17 Type II NADH: Quinone Oxidoreductases of Plasmodium Falciparum and Mycobacterium Tuberculosis. Kinetic and High-Throughput Assays' in: Allison, W. S. and Scheffler, I. E., (eds) Methods in Enzymology, 456, San Diego, Calif., Academic Press, pp. 303-320.

This list was generated on Sun Jun 16 02:13:23 2019 BST.